It would be great if we could create multiple SMTP server configurations with atleast different from configurationsa and then be able to attach an SMTP server to a notification scheme.

These would enable, together with an EmailHander service, one to create projects with separate email addresses that would be completely integrated to JIRA.

For example:
One customer support project sends emails out as support@domain.com. JIRA EmailHandler listens to this box and creates comments from incoming email.

An internal helpdesk project could then be created that sends out emails as helpdesk@domain.com. JIRA EmailHandler could listen to this box and create comments from incoming email.

CreateIssueHandler would then be easier to configure since both projects have totally separate email addresses. No user needs to remember two email addresses to comment or create issues.