When attempting to adjust permissions in Confluence changes will not save/update

When logged in as an Administrator, and attempting to adjust the permissions of a space in Confluence (Server:Confluence 5.8.5)
I add the user or group (using "Edit Permissions"), and then check the boxes for the permissions I want to grant. I then click on "Save All" which fades and the page does not update and the button becomes unresponsive, I can still navigate around the page, check boxes, and even go to other parts of the site. The "Save All" button remains faded and the changes do not apply, even on a refresh.
I need to be able to adjust permissions for spaces.
Thanks,